If your desired mg/hr is:
If your desired mg/hr is: | at a 4 mg/mL concentration (1,000 mg in 250 mL), administer at: | at a 2 mg/mL concentration (1,000 mg in 500 mL), administer at: | at a 1 mg/mL concentration (1,000 mg in 1,000 mL), administer at: |
---|---|---|---|
50 mg/hr | 13 mL/hr | 25 mL/hr | 50 mL/hr |
100 mg/hr | 25 mL/hr | 50 mL/hr | 100 mL/hr |
150 mg/hr | 38 mL/hr | 75 mL/hr | 150 mL/hr |
200 mg/hr | 50 mL/hr | 100 mL/hr | 200 mL/hr |
250 mg/hr | 63 mL/hr | 125 mL/hr | 250 mL/hr |
300 mg/hr | 75 mL/hr | 150 mL/hr | 300 mL/hr |
350 mg/hr | 88 mL/hr | 175 mL/hr | 350 mL/hr |
400 mg/hr | 100 mL/hr | 200 mL/hr | 400 mL/hr |
900 mg/hr* | 225 mL/hr | 450 mL/hr | 900 mL/hr |
Dilute GAZYVA with 0.9% sodium chloride to achieve a final concentration ranging from 0.4 mg/mL to 4 mg/mL.
Do not use other diluents such as dextrose (5%).
If no infusion reaction or an infusion reaction of Grade 1 occurred during the previous infusion and the final infusion rate was 100 mg/hr or faster, infusions can be started at a rate of 100 mg/hr and increased by 100 mg/hr increments every 30 minutes to a maximum of 400 mg/hr
If an infusion reaction of Grade 2 or higher occurred during the previous infusion, administer at 50 mg/hr. The rate of infusion can be escalated in increments of 50 mg/hr every 30 minutes to a maximum rate of 400 mg/hr
Interested in more information about GAZYVA?
GAZYVA full Prescribing Information. South San Francisco, CA: Genentech, Inc.; 2022.
GAZYVA full Prescribing Information. South San Francisco, CA: Genentech, Inc.; 2022.
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Data on file. Genentech, Inc.
Data on file. Genentech, Inc.
Canales M, Buchholz T, Izutsu K, et al. Obinutuzumab short duration infusion in previously untreated advanced follicular lymphoma: results from the end of induction analysis of the phase IV GAZELLE study. Presented at ASCO 2021.
Canales M, Buchholz T, Izutsu K, et al. Obinutuzumab short duration infusion in previously untreated advanced follicular lymphoma: results from the end of induction analysis of the phase IV GAZELLE study. Presented at ASCO 2021.
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